When a 1,200-year-old corpse called the Iceman is discovered in the Alps, a Swiss professor, to avoid regulations, smuggles the samples into the United States. When a blizzard diverts the professor's flight to Chicago, Customs is hectic, and the professor mistakenly swaps his suitcase with Frank, a drug mule. A snow storm forces the professor to stop in the hamlet of Kirby, Wisconsin. He has no idea that he's carrying drugs and that his life is in jeopardy.

Between dangerous drug mules and infected tissue samples, many lives in the snow-bound village are in jeopardy.