Trip of a Lifetime is a science fiction, murder mystery, love story taking place around the year 2090. An apocalyptic climate on Earth makes it paramount for those aboard Laika II to seek habitation elsewhere. Meanwhile, back on Earth, conditions have become intolerable for those that remain, and the Skipper of Laika II is forced to abandon any plans to return home. Although the World Space Association (WSA) appears united in their mission, they are not without opposition from within. An assassin aboard Laika II is bent on thwarting the WSA's efforts and taking over the spacecraft.