Getting used to life back home in Deer Park, North Carolina, Sydney McCall and her right-hand tabby, Toby, are helping her sister Kat run the local animal shelter. Syd and Kat are all excited about the prospect of the shelter's newest fundraiser: shopping channel queen Ulla Townsend. Shelter admin Maggie Shayne vehemently refuses to have anything to do with the woman, but the fundraiser ensues as planned. That is, until Ulla turns up dead in the middle of the event.

The cause of death is determined to be an allergic reaction, but Syd and Toby are sniffing out something fishy. When Syd met Ulla, it was clear she was distasteful and rude. And right before the event, Syd spotted some behind-the-scenes drama between Ulla and her manager. As they begin to investigate, they realize there is no shortage of suspects, and Maggie is at the top of the list.

Now Syd and Toby must claw their way to the truth before everything goes paws up at their animal shelter in Death by a Whisker by national bestselling author T. C. LoTempio.