As Maggie Patterson runs her hand over the clothes in her closet and muses about the prosaic details of preparing for a shockingly personal murder trial, she is catapulted into the memories that led her to this moment. Piece by piece, she assembles the fragments of her past to make sense of a violent crime, the echoes of which ripple through her recollections.

Maggie and Cynthia meet as college freshmen and are seemingly destined to be best friends for life. As the years pass, however, Maggie's marriage and career lift her to success and wealth while Cynthia's jealousy and untreated mental illness cause their relationship to disintegrate. As the stories of the two women's lives unfold, Cynthia's paranoia and anger sour every relationship she has and turn even the people who have loved her most against her, ultimately bubbling over into an event that Maggie never sees coming.

Not a murder mystery in the usual sense, and spanning time and space, Sainted in Error delves into the tenacity of friendship and the damage that the stigma still attached to mental illness can do.