In a world where monsters called Yoma prey on humans and live among them in disguise, humanity's only hope is a new breed of warrior known as Claymores. Half human, half monster, these silver-eyed slayers possess supernatural strength but are condemned to fight their savage impulses or lose their humanity completely.

After finding herself mysteriously drawn to the lair of Riful of the West, Clare made contact with the fused form of Rafaela and Luciela, which Awakened and transformed into the terrible being known as the Destroyer. Now, the entire land of Lautrec is subject to its dreadful, relentless assault. It seems that nothing, and no one, can halt the devastation. But there may be one force that is greater still...