In Tsutomu Nihei's nightmare vision of the future, the N5S virus has swept across the earth, turning most of the population into zombie-like drones. Zoichi Kanoe, an agent of Toa Heavy Industry, is humanity's last hope, and he's not even human! With the help of Fuyu, a digitized intelligence built into the computer system of his Heavy Dual Coil motorcycle, Zoichi's search for the key to salvation will take him on a journey across surreal landscapes and hurl him into battle against mind-bending evil. Prepare yourself for the ultimate trip--prepare yourself for the world of BIOMEGA.

In a bid to remake the planet according to her design, Niarudi--Matriarch of the DRF--has unleashed the Reverse Morphic Polymer. This substance triggers a radical transformation of the earth, preparing it for restoration. Meanwhile, Zoichi goes all out to recover Eon Green, and Fuyu learns more about what happened on Mars seven hundred years ago--secrets that shed light on the unbelievable metamorphosis about to take place!