In Tsutomu Nihei's nightmare vision of the future, the N5S virus has swept across the earth, turning most of the population into zombie-like drones. Zoichi Kanoe, an agent of Toa Heavy Industry, is humanity's last hope, and he's not even human! With the help of Fuyu, a digitized intelligence built into the computer system of his Heavy Dual Coil motorcycle, Zoichi's search for the key to salvation will take him on a journey across surreal landscapes and hurl him into battle against mind-bending evil. Prepare yourself for the ultimate trip--prepare yourself for the world of BIOMEGA.

Zoichi Kanoe plunges into the depths of 9JO--an island city in the middle of the Pacific Ocean--in search of Eon Green, a girl with the power to transmute the N5S virus. He's not the only one looking for her, though... Agents of the Public Health Service's Compulsory Execution Unit are also in hot pursuit. Zoichi and his transhuman allies have no time to waste; the countdown to the zombie apocalypse has begun!