In a world where monsters called Yoma prey on humans and live among them in disguise, humanity's only hope is a new breed of warrior known as Claymores. Half human, half monster, these silver-eyed slayers possess supernatural strength but are condemned to fight their savage impulses or lose their humanity completely.

Galatea's plans to eliminate the Awakened former number 2, "Bloody" Agatha, have failed, but the arrival of Clare and her comrades turns the tide of battle. In the aftermath, Miria decides to finally share her shocking discoveries about the true nature of the Yoma, of the Organization and of the Claymores themselves.