After years of the deadly Affliction, those who remain--the surviving humans and the new generation of animal-hybrid children--are searching for answers. And one place in all the world seems to have them: northern Alaska.

It was in this faraway, frozen wilderness that the Affliction first took root, before eventually spreading its devastation throughout the globe. Gus, Jepperd, and their friends travel north to the remote research outpost where Gus was born in the hope that understanding the plague's source will lead to a cure.

What power was unleashed in the frozen tundra? Can it be stopped? Even if the survivors reach their goal, there might not be anything left of humanity to save...

Gus and Jepperd's postapocalyptic journey comes to a heart-stopping, heartbreaking conclusion in this final volume, written and illustrated by Jeff Lemire (Descender, Green Arrow) with additional art by Matt Kindt (Mind MGMT). Sweet Tooth Book Three collects issues #26-40, as well as never-before-seen sketches and an interview with the author and Damon Lindelof (co-creator of Lost and The Leftovers).