NTS follows the transformative journey of Meredith Fields as she navigates the tumultuous realities of her life in the 1970s and 80's. Struggling with self-doubt and an overactive imagination, Meredith finds her idealized version of life crumbling before her eyes. Her emotionally distant husband, Kenneth, her defiant daughter, Cameron, and the ever-changing social landscape all contribute to her growing confusion.

Against the backdrop of post-Vietnam War, the rise of the AIDS epidemic, and an influx of immigrants in US cities, Meredith grapples with what her role might be in this changing world. She begins to question her own beliefs and wrestles with the devastating consequences of her self-doubt as well as her hesitation to act on her intuitions, especially after the tragic death of her friend, Willow.

As she faces critical events, personal and professional, Meredith embarks on a profound journey of self-discovery. Along the way, she challenges cultural expectations, unpacks her own privilege, and learns to overcome her adversarial relationship with her body. Gradually, she begins to claim her place in the world and discover the power of her own contributions.

From the intimate and emotional prologue set in 1993, where Meredith reflects on her complex relationship with her daughter, to the final scenes where she encourages her students to dream and envision their future, A ROSE IN LITTLE FIVE POINTS explores themes of motherhood, identity, resilience, and self-acceptance. Through her experiences, Meredith learns to embrace heartache as a catalyst for change and growth, ultimately forging a stronger bond with her daughter and finding her own path towards fulfillment and happiness.