Regan "Roz" Osbourne is broke. Her ex-boyfriend won't take no for an answer, and no one is taking her art work seriously. So when a mysterious stranger offers her a million dollars and safety from her unstable ex in exchange for her left hand, she can't afford to refuse.

Immediately following the amputation, she's racked with insufferable phantom limb pain. Desperate for relief, she enrolls in an experimental drug trial. But this drug has a peculiar side effect--she develops a psychic connection to her missing limb. She soon discovers that Chicago's long-dormant Phantom Strangler is now wearing her hand and is using it . . . to kill.